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NIH RFA pragmatic clinical trials

The Request for Applications (RFA-RM-13-012), “Demonstration Projects for Pragmatic Clinical Trials Focusing on Multiple Chronic Conditions, ” has been published in the NIH Guide. The purpose of this RFA is to solicit applications for cooperative agreements for demonstration projects for efficient, large-scale, pragmatic clinical trials focused on management of patients with multiple chronic conditions. Trials must be conducted across two or more health care systems (HCS) and must be conducted as part of the NIH HCS Research Collaboratory supported through the NIH Common Fund (see ).

Awards made through this RFA will initially support a one-year milestone-driven planning phase (UH2), with possible rapid transition to the implementation phase (UH3) for a pragmatic trial demonstration project. UH3s will be awarded after administrative review of eligible UH2s that have met the scientific milestone and feasibility requirements necessary for the UH3 implementation phase, depending on the availability of funds. The UH2/UH3 application must be submitted as a single application; applicants should particularly note the specific instructions for each phase in this RFA. The deadline for applications is December 2, 2013

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Why is randomization important in clinical trials?

This is to avoid bias in a study.

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