IVF clinical trials Philadelphia
The Department of Obstetrics and Gynecology has a very active clinical research program in every subspecialty. In 2007, we established the Women's Health Clinical Research Center under the direction of Dr. Kurt Barnhart. Many faculty members are trained in epidemiology and biostatistics or public health. There are numerous clinical trials available in reproductive health, contraception, infertility, gynecologic oncology, urogynecology, and obstetrics. The Division of Reproductive Endocrinology and Infertility has been a member of the Reproductive Medicine Network since it was established in 1990, and is one of eight centers in the country carrying out large, multi-center trials in the area of male and female infertility, and reproductive disorders. The Division of Gynecologic Oncology participates in the clinical trials sponsored by the Gynecologic Oncology Group (GOG) and in the phase I and II clinical trials in ovarian cancer offered through the Center for Early Detection and Cure of Ovarian Cancer.
Reproductive Health / Infertility
Optimal treatment for women with a Persisting Pregnancy of Unknown Location - a Randomized Clinical Trial of women at risk for an ectopic pregnancy: Active Treatment versus Expectant Management (No Treatment) The “ACT or NOT TRIAL”
Reproductive Medicine Network
This is a multi-site randomized comparative efficacy trial of strategies to manage women identified to have a persisting pregnancy of unknown location (PPUL) (a nonviable gestation). Randomization will be into active versus expectant management. Additionally, women randomized to active management will be equally randomized between two active management strategies Active management A) Determine the location of the pregnancy by a uterine evacuation, followed by a pathologic evaluation. If no evidence of a uterine pregnancy is determined (i.e. non-visualized ectopic pregnancy), begin methotrexate dosage (50 mg/m2 given as an intramuscular injection) B) Empiric methotrexate treatment without determination of the location of the gestation. Target enrollment at Penn is 50 women. Principal Investigator: Dr. Kurt Barnhart
A phase IIb randomized, double blind, comparative study to assess the efficacy, safety, tolerability and inhibition of ovulation of two continuous regimens of oral daily 5 mg or 10 mg of ulipristal acetate (UPA), versus a dose of 5.0mg UPA for 24/4 days.
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Book (LAP LAMBERT Academic Publishing)
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Discovery by biomedical research of new and improved interventions can get into the bucket of implementation.
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