Clinical trials for IVF in PA

Researchers at Penn Fertility Care and Penn Ob/Gyn Care are conducting the Periconception and Antepartum Nutrition, Developmental Outcomes and Reproductive Ability (PANDORA) trial, a clinical study that examines maternal nutritional and environmental factors to determine their potential as precipitants for offspring health and fertility risks in adulthood.

Fetal growth is driven in large part by the environment in utero and by adaptations of the fetus to maternal conditions. While significant attention has been focused on drastic maternal deprivation during mid to late gestation as a basis for altered fetal growth, subtle environmental perturbations throughout gestation may also impact fetal organ development in the absence of overall growth restriction. Dietary and environmental exposures in and around the time of conception appear to be critical for conditioning fetal growth patterns.

There is good evidence, as well, that the risk of obesity, hypertension and diabetes in adulthood may be promoted by fetal responses to maternal conditions and exposures during pregnancy. Such altered responses include changes in metabolism and hormone production, as well as changes in tissue sensitivity to hormones that may affect the development of various organs and lead to persistent alterations in physiology.

In addition, a growing body of literature suggests a link between maternal environment, fetal growth restriction and poor odds of reproduction in adulthood. The PANDORA Trial was initiated at Penn Fertility Care to examine these concerns.

About PANDORA

Objectives: The primary aim of PANDORA is to investigate the association between maternal levels of folate, vitamin B12, Vitamin D, and Bisphenol-A and neonatal markers of growth and ovarian sufficiency. The secondary aim of the study is to test the association between these same maternal exposures and time to pregnancy and risk of miscarriage.

Methods: In this prospective study, maternal exposures will be measured both prior to conception and during pregnancy. Samples of maternal urine and serum will be collected at specific intervals preconception and if pregnancy is achieved, at 18-20 weeks gestation. The principal clinical outcome
Clinical Research in Fertility Care: The PANDORA Trial Center for Research on Reproduction and Women’s Health of interest is birth weight.Additional outcomes (collected from umbilical cord blood at delivery) include biomarkers associated with neonatal growth, infant growth potential, and ovarian development.

Participants will be healthy women between 28 and 45 years of age either attempting pregnancy spontaneously or seeking infertility care with in vitro fertilization. A brief questionnaire will be administered at study enrollment that addresses diet and vitamin/supplement intake. At delivery, umbilical cord blood will be collected to measure the following metabolic and reproductive biomarkers: IGF-1, IGF-2, IGFBP3, insulin, leptin and Anti-Mullerian Hormone (AMH, which will be measured in female neonates only).

During the study, participants are provided with ovulation predictor kits and home pregnancy tests at no cost; study related transportation costs are also covered. Enrolled study participants are also eligible to receive an early first trimester pregnancy ultrasound at no cost.

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Popular Q&A

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Do you know of any "paid" clinical trials for Anxiety, Panic attacks, or sleep disorders in Lancaster PA ?

Do you know of any "paid" clinical trials for Anxiety, Panic attacks, or sleep disorders in Lancaster PA ?
I am only looking for Paid clinical trials.
Please, we have no income, and 5 kids.

I know the Penn State Hershey Med Center occasionally has paid clinical trials for those things. Maybe you can look on their website or call. It shouldn't be too bad of a drive depending on where live in Lancaster.

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